Biomedical Research

I would love the opportunity to expand my skills in the STEM field. The start-up I currently work at as the research scientist is quite small and limited to only a few assays, so I'm looking for more critical and faster paced opportunities!

**Technical** **Areas of Expertise** 

*   Genetic variation and its role in disease development
*   CRISPR gene editing and other molecular techniques for targeted genetic modifications
*   Integration of genomic data into precision medicine and personalized genomics
*   Embryology and human development studies
*   Statistical analysis methods in genetics research
*   Bioinformatics and computational genomics applications for interpretation of genomic data, sequence alignment, genome assembly, and functional annotation
*   Next-Generation Sequencing (NGS) technologies for identification of genetic variations, disease-associated mutations, and structural genomic alterations
*   Heritable syndromes, mitochondrial, and neurological disorders
*   Cancer genomics research and targeted gene therapy
*   Ethical, Legal, and Social Implications (ELSI) of Genetics awareness

**Tools and Databases**

*   QIAGEN Ingenuity Pathway Analysis
*   The Cancer Genome and Proteome Atlas
*   UCSC Genome Browser
*   Online Mendelian Inheritance in Man (OMIM)
*   Ensembl Genome Browser
*   Catalog of Somatic Mutations of Cancer (COSMIC)
*   Human Genome Organisation (HUGO) Resources
*   NCBI databases such as BLAST, GenBank, HGNC, and dbSNP

**Key Seminars**

*   _Human Genetics and Genomics Seminar_ by Dr. Dan Handley
*   _Biomedical Research_ course training by CITI
*   _The Future of Genomics and Precision Health_ by Niki Sidiropoulus, M.D.
*   _Genome Mapping Nomenclature_ Workshop by Dr. Ros Hastings
*   _Stability of Polygenic Scores Across Discovery GWAS_ by Laura Schultz, Ph.D.

Southern California University of Health Sciences

*   Ex-Vivo Chicken Embryo Culture (2020): fertilize gametes, design a controlled culture system for incubation and monitoring, studies key developmental milestones and the genetic factors influencing the establishment of body axes and the development of major organs, through late-stage development and analysis.
*   Native Bee Gene Pool Sequencing (2020): fieldwork and pollen collection, DNA isolation from pollen samples, PCR amplification of extracted DNA, agarose gel electrophoresis, through data analysis and interpretation.
*   Leech Gut Microbiome DNA isolation (2019): fieldwork and leech collection in the Great Basin, spread-plating, incubation and growth of bacterial colonies, streak-plating for isolation, biochemical assays for enzymatic activities, substrate utilization, and metabolic profiling of bacterial isolates, followed by DNA isolation and PCR amplification to determine the gut microbiome of non-bloodsucking leeches.

Southern Utah University

*   Demonstrate effective leadership as the supervisor of the laboratory team, overseeing the coordination of activities among junior technicians and research assistants.
*   Proficiently conduct RT-qPCR assays while providing guidance and mentorship to foster a collaborative and efficient work environment
*   Manage critical aspects of laboratory operations, including Quality Assurance/Quality Control (QA/QC) procedures, optimization of Standard Operating Procedures (SOPs), and comprehensive training of laboratory personnel

Lead Lab Technician

*   Design and develop diagnostic assays by creating tailored oligonucleotide sequences and probes optimized for PCR amplification. 
*   Analyze and derive insights from data obtained through molecular diagnostic testing, facilitate effective inter-laboratory collaboration, and contribute to the acquisition of CLIA and COLA certification for high-complexity Laboratory-Developed Tests (LDTs).

Anna Colclasure

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