
Principal Scientist - Upstream Process Development
We are looking for an experienced Principal Scientist - Upstream Process Development to join our BioMarin Pharmaceutical team. In this role, you will be responsible for leading the development and optimization of upstream manufacturing processes and unit operations for therapeutic proteins and enzyme-based products.You should have a PhD in biochemistry, chemical engineering, or a related field, with at least 8-10 years of relevant experience in bioprocess development. Additionally, you must have a thorough understanding of molecular biology, cell culture, and protein purification, as well as experience in troubleshooting and process optimization.The ideal candidate for this role will have strong interpersonal and communication skills, excellent problem-solving abilities, and the ability to work in a fast-paced environment. You should be self-motivated and have a passion for scientific excellence. If you are an experienced Principal Scientist with the qualifications and skills described above and have a desire to make a positive contribution to the development of biopharmaceuticals, then this may be the perfect role for you.
Responsibilities:
- Lead the development and optimization of upstream manufacturing processes and unit operations for therapeutic proteins and enzyme-based products.
- Provide technical expertise and scientific leadership to develop and implement strategies for process improvement.
- Establish and maintain collaborative relationships with internal and external stakeholders.
- Develop and execute experiments to evaluate new process technologies and approaches.
- Analyze data to identify trends and optimize process parameters.
- Design and implement process control strategies and other process analytical technologies.
- Troubleshoot and resolve issues related to process development and optimization.
- Prepare reports and presentations outlining process development results.
- Provide mentorship, guidance, and training to junior scientists.
- Stay up-to-date on industry trends and best practices.
Biochemistry
Chemical Engineering
Master's Degree Or Higher In The Field Of Biotechnology
Or Related Discipline
Minimum Years Of Directly Related Experience In The Biopharmaceutical Industry
Proven Track Record Of Successful Process Development And Technology Transfer Experience
Extensive Experience In Cell Culture
Fermentation
And Other Upstream Unit Operations
Knowledge Of Relevant Regulatory Guidelines And Requirements
Proven Ability To Lead And Mentor A Team Of Scientists
Project Management
Data Analysis
Quality Control
Scientific writing
Process validation
Process optimization
Regulatory compliance
Cell Culture
Cost reduction
Analytical Chemistry
Method development
Fermentation
Technology Transfer
Bioprocessing
Scale-Up
Communication
Leadership
Time management
Interpersonal Skills
creativity
Organization
Critical thinking
collaboration
Adaptability
Problem-Solving
According to JobzMall, the average salary range for a Principal Scientist - Upstream Process Development in Novato, CA, USA is between $137,182 and $220,741 per year. This range includes base salary, bonus, and other forms of compensation. The exact salary an individual earns will depend on factors such as experience, education, and other qualifications.
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BioMarin Pharmaceutical Inc. is an American biotechnology company headquartered in San Rafael, California. It has offices and facilities in the United States, South America, Asia, and Europe. BioMarin's core business and research is in enzyme replacement therapies.

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